Syndrome.

by Thomas Hoover.

SYNDROME

They were promised a miracle cure for the deadly diseases destroying their lives. It seemed too good to be true, but to the desperate and dying it was the only chance for survival. Now they're part of a bizarre secret experiment that reverses the aging process - an experiment gone out of control. To stop the madness, one woman must enter a shocking nightmare world, where scientists control your body - and your mind - and living makes you beg for death ...

In her mid-thirties, Alexa Hampton runs her own interior design firm in New York's Soho and has a daily run to keep fit. But now her world is narrowing as a childhood heart mishap increasingly threatens to lethally impact her life. Then out of nowhere her black-sheep younger brother appears and insists she go to a clinic in New Jersey to enter stem-cell clinical trials that are working wonders. The clinic is owned by her brother's boss, the eccentric millionaire Winston Bartlett.

Also interested in the clinic is the medical reporter Stone Aimes, who's hoping to penetrate Bartlett's veil of secrecy and find out what's going on there. He has personal as well as professional reasons for wanting to get closer to Winston Bartlett. He is also a long-ago lover of Alexa's and still carrying something of a torch for her though they have long been out of touch.

As Alexa investigates the clinic, their paths cross and together they slowly uncover the horrifying truth about what can happen when stem- cell technology is taken to its ultimate limit. A bizarre secret experiment to reverse the aging process has gone out of control.

Winston Bartlett's young mistress, the TV personality Kristen Starr, had an anti-aging procedure that went awry and now all her cells are being replaced with new. The side effects are horrific. No one can stop what is happening: she is growing younger, destined to become a child again. Bartlett has had the same procedure and now he knows he's next.

It's only a matter of time till he too regresses to childhood, and then ... no one knows.

Alexa and Stone become prisoners in the clinic and then Bartlett and his Dutch medical researcher Karl van der Vliet begin a bizarre experiment on Alexa, hoping to produce antibodies to save Kristen, and Bartlett. In a stunning, blazing finale, Alexa turns the tables on them all, only to discover that she's now, suddenly unlike anyone else who has ever lived.

Chapter 1

_Sunday, April 5

6:49 A.M.

_

Alexa Hampton was awakened by a sensation in her chest. The alarm wasn't set to go off for another eleven minutes, but she knew her sleep was finished.

Not again! She rolled over and slapped the blue pillowcase.

That little sound from her heart and the twinges of angina, that catchall for heart discomfort, was happening more and more now, just as Dr. Ekelman had warned her. But she wasn't going to let it stop her from living her life to the fullest as long as she could, and right now that meant having her morning run.

She curled her legs around, onto the floor, reached for a nitroglycerin tab, and slipped it under her tongue. Known as a vasodilator, the nitro lowered the workload on her heart by expanding her veins. It should get her through the workout ....

That was when she felt a warm presence rub against her leg.

"Hi, baby." Still sucking on the tab, she reached over and tousled Knickers' gray-and-white hair, then pushed it back from her dog's eyes.

Her Old English sheepdog, a huge hirsute off-road vehicle, turned and licked her hand. Knickers was ready to hit the trail.

She'd been dreaming of Steve when the chest tightness came, and maybe the emotion that stirred up had caused the angina. She still dreamed of him often, and it was always someplace where they had been together and loved, and they were ever on the brink of some disaster. That frequently caused her heart to race, waking her.

This time it was the vacation they took six years ago, in the spring.

They were sailing off Norman's Cay in the Bahamas. She was raising the jib, the salt spray in her hair, but then she looked up and realized they were about to ram a reef.

She felt the dreams were her unconscious telling her to beware her current precarious condition. If, as is said, at the moment of your pa.s.sing, your entire life flashes before your eyes, then the dreams were like that, only in slow motion. It was as though she were being prepared for something. The dreams were a premonition. She had a pretty good idea of what.

Ally had had rheumatic fever when she was five, which went undetected long enough to scar a valve in her heart. The formal name was rheumatoid aortic stenosis, a rare, almost freakish condition that had shaped her entire life. The pediatrician at Mount Sinai had told her parents they should think twice about allowing her to engage in any vigorous activity. Her heart's function could be deceptively normal during childhood but when she got older ... Well, why stress that organ now and hasten the inevitable day when it could no longer keep up with the rest of her body?

She had refused to listen. She'd played volleyball in grade school, basketball in high school, and she became a disciplined runner when she went to Columbia to study architecture. She wanted to prove that you could make your heart stronger if you believed hard enough and wanted to live hard enough.

Now, though, it was all catching up. She'd had a complete checkup two weeks ago Thursday, including a stress test and

Doppler echocardiogram, and Dr. Ekelman had laid out the situation, gazing over her half-lens gla.s.ses and pulling at her chin. The normal twinkle in her eyes was entirely absent.

"Alexa, your condition has begun worsening. There's a clear aortic murmur now when your pulse goes up. How long can you go on living in denial? You really can't keep on stressing your heart the way you have been. You can have a normal life, but it's got to be low-key. Don't push your luck."

"Living half a life is so depressing," she'd declared, not entirely sure she meant it. "It's almost worse than none at all."

"Ally, I'm warning you. If you start having chest sensations that don't respond to nitro, call me immediately. I mean that. There's a new drug, Ranolazine, that temporarily shifts your heart over to using glucose as a fuel instead of fatty acids and provides more energy for a given amount of oxygen. It will make the pain back off, but I only want to start you on that as a last resort. That's the final stop before open- heart surgery and a prosthetic aortic valve."

Day by day, the illusion of normality was getting harder and harder to maintain. She had been playing second violin in an amateur string quartet called the West Village Oldies, but a month ago she'd had to drop out. She didn't have the endurance to practice enough to keep up with the others. Blast. It was having to give up things you love that really hurt.

Still, she was determined to keep a positive att.i.tude. There was your heart, and then there was heart. You had to understand the difference.

She lay back to wait for the alarm and try to compose her mind. This Sunday morning was actually the one day of the year she most dreaded.

The anniversary.

It had been back when Steve was still alive. They were living in the Chelsea neighborhood of New York, in a brownstone town house they were renting. The rent was high, but they were doing all right. Steve was a political consultant, who had helped some fledgling candidates overcome the odds and win important elections. In between campaigns here, he also got work in the nominal democracies in Latin America.

She was a partner in a small firm of architects who had all been at Columbia together and decided to team up after graduation and start a business. There were four of them--she was the only woman--and it was a struggle at the beginning. For the first three years they had to live off crumbs tossed their way by the big boys, subcontracts from Skidmore and other giants. They felt like they were a high-paid version of Manpower, Inc., doing grunt work, designing the interiors of shopping malls in the Midwest and banks in Saudi Arabia, while their prime contractors got to keep all the s.e.xy, big-budget jobs that called for creativity, like a gla.s.s-and-steel office tower in L.A.

But then interesting work finally started to trickle in, including a plum job to convert a ma.s.sive parking garage in Greenwich Village into a luxury condominium. Through a wild coincidence (or luck) she had personally designed the apartment she later ended up buying for herself.

Just when everything seemed to be turning around and going her way, an event happened that stopped her in her tracks. Five years ago on this very day, April 5, her mother, Nina, phoned her at six-thirty in the morning and, in a trembling voice that still haunted, announced that her father was dead.

Arthur Wade Hampton was fifty-nine and he'd been cleaning his Browning shotgun for an early-morning hunting trip to Long Island--so he'd claimed the night before--and ... she was awakened by the explosion of a discharge. A horrible accident in the kitchen of their co-op in the West Village.

Like Hemingway. Thinking back, they both realized it was the wrong time of year to hunt anything--but they both also knew he wanted the world to think that. Moreover, it was precisely the kind of vital lie they'd need to get through the pointed questions and skeptical looks that lay ahead. It was a knowledge all the more palpable for being unspoken.

There's no time like those first moments after a tragedy to create a special reality for yourself.

It was only in the aftermath that she managed to unravel the reason. He owned and operated an interior-design firm in SoHo called Citis.p.a.ce, and he had mortgaged it to the hilt. He was on the verge of bankruptcy.

(That was why Ally had not spoken to her younger brother, Grant, in the last 4 1/2 years.)

She felt she had no choice but to try to salvage what was left of the business and her father's reputation. She left the architectural firm and took over Citis.p.a.ce. It turned out she was easily as good an interior designer as she had been an architect, and before long she had a backlog of work and was adding staff. She restructured and, eventually paid off the firm's debt; it was now on a sound financial footing.

These days Citis.p.a.ce specialized in architectural rehabs in the Greenwich Village area, with as many SoHo and TriBeCa lofts as came her way. The work was mostly residential, but lately some lucrative commercial office jobs were beginning to walk through the door.

Anything dependent on luxury real estate can be vulnerable in dicey times, but she'd been able to give everybody a holiday bonus for the past couple of years. She'd even given herself one this year, in the form of this new condo apartment, which she loved.

Another major reason she'd taken over Citis.p.a.ce was to try to provide her mother some peace and dignity in her twilight years. But then, irony of ironies, Nina, who was a very lively sixty-six, was diagnosed eighteen months ago with early-onset Alzheimer's. Now her consciousness was rapidly slipping away.

All the things that had happened over the last few years had called for a special kind of heart. She had known Steve Jensen, a freelance political consultant, for eight years, and they'd lived together for three of those, before they got married. He was warm and tender and s.e.xy, and she'd envisioned them in rocking chairs forty years down the road. They'd been married for only six months when he got a job to help reelect the president of Belize. At first he was reluctant, concerned about human rights issues, but then he decided the other candidate, the alternative, was even worse. So he went.

How many things can be destined to go wrong in your life? Exactly seven months after her dad died, she received a phone call from the American Emba.s.sy in Belmopan, Belize. Steve had been flying with the presidential candidate over a stretch of southern rain forest in a single-engine Cessna when a sudden thunderstorm came out of the Caribbean and the plane lost radio contact. That was the last, etc.

She rushed there, but after two weeks the "rescue" officially became a "recovery" mission. Except there was never any recovery. After two months she flew back alone, the loneliest plane ride of her life.